賴昆佑
簡汎清

Surface-enhanced Raman scattering (SERS) is a transformative technique known for its exceptional sensitivity and specificity in the domain of biomolecule detection and disease identification. Cancer diagnosis, a realm where early detection plays a pivotal role, has made much progress through SERS. This study embarks on the mission to harness the power of SERS, with a dual aim of detecting lung cancer and categorizing its various stages. The research incorporates Quantum Wells (QWs) into SERS substrates and hinges on optimizing the thickness of Titanium (Ti) adhesion layers. The synergy of these elements, QWs-SERS, emerges as a promising tool for diagnosing lung cancer. The SERS substrate featuring Ti adhesion layers exhibits an improved linear relationship between peak intensity, notably at wavenumber 1525 cm⁻¹, and different stages of lung cancer. This study holds great significance for cancer diagnosis as it not only offers the ability to distinguish different cancerous states but also opens a path for rapid (< 30 min) cancer screening.