賴昆佑

Surface-enhanced Raman spectroscopy (SERS) has become a powerful tool in material and life sciences due to its inherent characteristics, such as fingerprint recognition capabilities and high sensitivity. This work presents a new SERS biosensor substrate design, using InGaN quantum wells (QWs) and gold nanoparticles (Au NPs) for glucose detection in a chemically defined (CD) solution. The SERS intensity of glucose can be enhanced by two orders of magnitude when the Au thickness for NPs was increased from 40 nm to 50 nm, and QW number from 0 to 3. The QWs embedded at shallow depths from the surface allows the SERS substrate to capture electrons and pump them (through laser excitation) to the hot spots, increasing the SERS intensity. This QW-based SERS biosensor can detect the glucose in CD with the concentration down to 0.5 g/L (2.8 × 10−3M) and exhibit the linear dynamic response in the range of 0.5-5 g/L (2.8 × 10−2 − 2.8 × 10−3M).