賴昆佑
簡汎清

Surface-enhanced Raman scattering (SERS) is a light-intensifying technique that combines plasmonic enhancement and chemical enhancement, significantly boosting Raman signals. This technique delivers structural information produced by particular molecular vibrations, and has many advantages, such as high sensitivity, high selectivity and rapid-detection, etc. In this study, a nitride SERS substrate decorated by Al nanoparticles was fabricated for the detection of deoxyribonucleic acid (DNA). The substrate was built with InGaN quantum wells (QWs), from which abundant electronic charges, under laser excitation, were transferred to the SERS-active regions and thereby amplified SERS signals. The Al nanoparticles were adopted to induce localized surface plasmon resonance at the excitation wavelength of 488 nm. It was found that the label-free Al-decorated QW SERS substrate can achieve the detection limit of 10-6 M for 19-mer cytosine single-stranded DNA. The nitride substrate was also able to differentiate the hybridization event of circulating tumor DNA.